High levels of serum vitamin D-binding protein in patients with psoriasis: A case-control study and effects of ultraviolet B phototherapy

The role of vitamin D in psoriasis remains contradictory despite the fact that analogues constitute an established treatment for psoriasis. It has been proposed ability to exert anti-inflammatory effects might not depend solely on concentration serum 25(OH)D but also D-binding protein (DBP). High concentrations DBP diminish D’s biologic action. aims this study were (i) analyze levels DBP, total and calculated free patients with compare results healthy controls (ii) effect ultraviolet B (UVB) phototherapy levels. Caucasian subjects (n = 68) active plaque compared a population-based sample men women 105), matched age sex. Season enrollment was taken into consideration. studied before after UVB phototherapy. severity disease as Psoriasis Area Severity Index (PASI). index higher (P= 0.004, P 0.045 < 0.0001, respectively). did change phototherapy, whereas increased intact parathyroid hormone (iPTH) decreased (P 0.001 both). improved PASI 0.001). There no correlation between or PASI. Measurement is recommended when evaluating status imply disturbed pathway warrants further investigation. Direct measurement 25(OH)D, instead circumvents abnormally high could be considered.